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dna helicases การใช้

ประโยคมือถือ
  • The DNA helicases and polymerases must remain in close contact at the replication fork.
  • DNA helicases are responsible for unwinding the double-stranded DNA during chromosome replication.
  • The protein made by the gene belongs to a family of enzymes known as DNA helicases.
  • RNA helicases and DNA helicases can be found together in all the helicase superfamilies except for SF6.
  • Subsequent research has shown that DNA helicases form dimers in many eukaryotic cells and bacterial replication machineries stay in single intranuclear location during DNA synthesis.
  • Conservation of helicase motifs in eukaryote CSB is evident; all seven major domains of the protein are conserved among numerous RNA and DNA helicases.
  • The N-terminal region has homology to several conserved domains of DNA helicases belonging to superfamily II, although XPF is not a DNA helicase.
  • The N-terminal area has homology to several conserved domains of DNA helicases belonging to superfamily II, although XPF is not a DNA helicase.
  • To synthesize DNA, the double-stranded DNA is unwound by DNA helicases ahead of polymerases, forming a replication fork containing two single-stranded templates.
  • In the replication factory model, after both DNA helicases for leading strands and lagging strands are loaded on the template DNAs, the helicases run along the DNAs into each other.
  • The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities.
  • DNA polymerases are then used to extend the primers annealed to the templates to produce a double stranded DNA and the two newly synthesized DNA products are then used as substrates by DNA helicases, entering the next round of the reaction.
  • He is one of the world's foremost experts on RecA, the defining member of a ubiquitous class of DNA strand-exchange proteins that are essential for homologous recombination, a pathway that maintains genomic integrity by repairing broken DNA . His lab has made significant contributions to the fields of DNA repair, homologous recombination and the biophysics of DNA helicases.